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It was shown that 8 weeks of swimming exercise significantly upregulated Drp1, OPA1, and Mfn2 expression, restored hepatic mitochondrial fusion/fission homeostasis, and upregulated P-AMPK/AMPK, SIRT1, and PGC-1 and their target genes NRF1, NRF2, and TFAM expression

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HMSC-E4 retained typical hMSC morphology, surface markers, and viability, but showed a 10,000-fold increase in Exendin-4 mRNA and a 20-fold rise in protein levels